There are every old Subspace enemies but also new one:
- Banzaï Bill: Bigger health and stronger then Bullet Bills. However, it is stompable.
- King Bill: The largest enemies but also the toughest does to their enormous health. It can still being captured as a Trophy.
- Blue Koopa: An old type of Koopa. They are timid as they don't want player to steal their Shell. Blue Paratroopa is faster then the other two Koopa type but also a bit weaker.
- Bonker: A tough Kirby enemy. It was a mid-boss. It swing hammer and throw coconuts.
- Bugzzy: Another tough Kirby enemies. It throw severly the player. It also use their little ladybugs to attack you at distance...maybe.
- Ice Primid and Thunder Primid: Two new type of Primid. It spit ices and thunders, respectively.
- Space Pirate: Their weapon was vary but also a bit healthy. They are the enemies of Samus.
- Blumid: A blue Primid that can swim. It also have a month to bite you.
- Ro-Bowser: A robotic version of Bowser...They attack the same as Bowser but when they gather up...It gotta be a pain!
- Robo-De: Robotic version of King Dedede...you know the rest.
- Eggman Bots: Classic enemies of Sonic. They are all form Sonic the Hedgehog 1.
- Wily Bots: Classic enemies of Mega Man. They are all form Mega Man 1.
- Rainbow Primid: The rarest of all Primid. It alway drops very rare items.
- Golden Primid: The strongest of all Primid, only lose to King Bill. It can use Item but it use it moves unfairly! Unless it weakened by being damaged...! You got it!
- Those enemies will join you if you throw a Chimestry Bomb at them, a Chapter Mode exclusive item.
- Any of those enemies are avalable in every stages except in Boss Battles Chapter in Easy Mode. That mean you will meet a Golden Primid at the beginning.
- The Beta Enemy are Luigi-Bots, however it is removed for unknown reason. However, you see four of them in the Scene where it attacks Mario but ended up to be destroyed by Bowser.