Super Smash Bros. Madness has bosses, similar to Super Smash Bros. Brawl. This is a list of the bosses and the strategies to defeat them. The list is not in a certain order.
|Image||Name||Series||Strategy||Stage Description||Theme||Faced In|
|Big Bob-Omb||Mario (series)||
King Bob-Omb stands on one end of the platform you fight on. He throws Bob-Ombs at you and can even pick you up and throw you off the stag. The idea is to pick up the Bob-Ombs he throws and throw them back at him, stunning him. He is then able to be damaged. At one-fourth health, he begins to run around the stage, releasing Bob-Ombs as he goes.
|King Bob-Omb is faced on top of the mountain in Bob-Omb Battlefield. It is flat and is floating in the air, similar to Final Destination.||Story Mode, Boss Battles|
Kraid stands in the background, shooting spikes at the platform you stand on and trying to claw at you. In order to hit him, you must attack the bombs that fall from the sky, damaging Kraid. At one-fourth health, Kraid begins to jump around, sending acid waves at you. When defeated, Kraid sinks into the acid.
|Kraid is fought in Brinstar Depths from Super Smash Bros. Melee. The stage now extends to some floating platforms to the left. Kraid is now much larger than in Melee.||Story Mode, Boss Battles|
|Dark Link||Zelda (series)||
Instead of a stamina fight, you must fight Dark Link like in a normal match. He fights very similarly to Link, but some attacks are strengthed. He is the only boss to pick up items and use them to his advantage.
|Dark Link is fought in his room from Ocarina of Time. It is completly flat and has no pits, similar to Bridge of Elden from Brawl.||Story Mode, Boss Battles|
|Shadow Lugia||Pokemon (series)||
Shadow Lugia is a flying enemy, much like Rayquaza from Brawl. It sends energy beams, blasts of winds, and whirlpools at you. At half-health, it attacks faster and begins to send tidal waves at you. At one-fourth health, Shadow Lugia sends black energy beams out of the sky to hit you with.
|Shadow Lugia is fought on a sailing cruise ship. Water surrounds the boat.||Story Mode, Boss Battles|
Zero begins as his first form in Kirby's Dream Land 3. He fires energy beams at you and Dark Matter sometimes appears and begins to swipe a sword at you before jumping away. Once defeated, Zero transforms into 0² and begins to fight. 0² appears in the background and can swing its wings at you, fire energy beams from its eye, and even slam itself into the flatform you stand on. At half-health, 0²'s tail turns into a cactus and it can swing the cactus at you.
|Zero is fought on a crumbling Fountain of Dreams. His second form is fought in a flat area where he was fought in Kirby 64.||
||Story Mode, Boss Battles|
|King Hippo||Punch-Out (series)||King Hippo fights with only his fists, similar to Little Mac. King Hippo occasionally punches with more damage.||King Hippo is fought in a flat boxing ring.||Story Mode, Boss Battles|
|250px||Inferno||SoulCalibur (series)||Inferno fights with a blazing sword. Inferno can also shoot flames at you and may jump around, setting whatever it lands on ablaze.||Inferno is fought in a flaming field. A few small hills can be walked on.||Story Mode, Boss Battles|
|||Master Hand||Super Smash Bros. (series)||Master Hand has his same moveset from Brawl.||Master Hand is fought on Final Destination.||Story Mode, Classic Mode, Boss Battles|
|Crazy Hand||Super Smash Bros. (series)||Crazy Hand has his same moveset from Brawl.||Crazy Hand is fought on Final Destination.||Classic Mode, Boss Battles|
|||Hand Overlord||Super Smash Bros. (series)||The Hand Overlord is a giant mask with a top hat. He is considered the final boss of the game. He attacks using lasers, missiles, and energy beams coming out of his mouth. At half-health, a very weakened Master Hand and Crazy Hand come to assist the Hand Overlord. He can only be defeated when the two hands are beaten.||The Hand Overlord is fought on Final Destination.||Story Mode, Boss Battles|