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In the New Fantendoverse, it still exists within Noah with it's own district. It is mentioned during Strafe: Warzones and Leah plans to find a cure for it but got horribly sidetracked and seems to have forgotten about her plans to cure it as the story ends.
The Rot causes the host's body to slowly decay over time, reducing their life expectancy by a large time. A host of the Rot can be identified by their pale grey skin colour, hair loss, and a lack of fingernails or toenails.
In the latest stages, the host's nose, ears, fingers and toes are likely to simply fall off before they die a short time afterwards.