Pokémon Kill la Kill Version is a special spin-off of the core Pokémon games. It is based on the manga Kill la Kill which also has its own anime series. As in the manga the Elite Four takes the place of the normal Elite Four of the Pokémon games. Unlike most Pokémon games you can only play as one character and have no choice to pick a gender.
The plot is similar to the first Pokémon games; Red and Blue.
Illustrating the original Pokémon gameplay concepts, the player begins his game in Honnō City, a small town in the Kanto region, on the same day as his former best friend and now rival. Aikurō Mikisugi calls the player to his laboratory, and allows the player to choose from the three Kanto starter Pokémon: the Grass-type Bulbasaur, the Fire-type Charmander, or the Water-type Squirtle. After the rival displays jealously, he chooses the starter that has a type advantage against the player's chosen starter and challenges the player to a preliminary battle. Afterwards, the player leaves for his journey across the region, challenging 8 Gym Leaders and other Trainers until he reaches the ultimate goal: the Pokémon League at the Honnōji Plateau.
Along the way, the player will meet up with his rival and best friend several times and have multiple run-ins with the insidious Revocs Corporation, a criminal group that seeks to use Pokémon for their own gain. The player will ultimately find out that the boss of this evil group, Ragyō Kiryūin, is actually the final Gym Leader in the game.
At the end of the game, the player will have a battle against the Champion, Satsuki Kiryūin, after beating the Elite Four.
After the credits, the player will gain access to Cerulean Cave in Cerulean City and be able to battle strong Pokémon. The player will be able to battle and capture the strong legendary Pokémon Mewtwo.
Players are introduced to the first eight Pokémon Gyms, each with their own Pokémon that suit their powers and personalities in the manga.
The Elite Four of Kanto are a step above the rest, all located at Indigo Plateau and ready to take on all challengers. The final battle is against the Pokémon Champion, the rival.
The Revocs Corporation consist out of many grunts that you'll battle along the way, although three of them are the most important. Their leader Ragyō Kiryūin who you don't fight until the gym battle, Nui Harime who you'll fight during the game and Rei Hōōmaru after you have become champion.
Each game contains pre-recorded data on 151 different species of Pokémon, including Mew, a Pokémon unavailable to players of either game under normal conditions. Despite this, not all Pokémon are available to the player, regardless of version; trades must occur between players in order to complete their Pokédex without the use of cheats or glitches. Mew is the only Pokémon in these games that must be acquired through attending either a Nintendo sponsored event, a glitch, or cheating.
- Ryūko Matoi - main protagonist (Red)
- Satsuki Kiryūin - rival/ champion (Blue)
- Mako Mankanshoku - best friend (Leaf...kinda)
- Aikurō Mikisugi - Professor Oak
- Takaharu Fukuroda - Brock (Gym Leader)
- Omiko Hakodate - Misty (Gym Leader)
- Kaneo Takarada - Lt. Surge (Gym Leader)
- Kusanosuke Yaguruma & Kusatao Uwabami - Erika (Gym Leader)
- Maiko Ōgure - Koga (Gym Leader)
- Shirō Iori - Sabrina (Gym Leader)
- Tsumugu Kinagase - Blaine (Gym Leader)
- Ragyō Kiryūin - Giovanni (Gym Leader/ antagonist)
- Hōka Inumuta - Lorelei (Elite Four)
- Ira Gamagōri - Bruno (Elite Four)
- Nonon Jakuzure - Agatha (Elite Four)
- Uzu Sanageyama - Lance (Elite Four)
- Nui Harime - second in command antagonist
- Rei Hōōmaru - Archer (after story antagonist)