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Mario and Luigi: Rebirth of Death is an E10+ rated game and the fifth installment of the Mario and Luigi series, succeeding Mario and Luigi: Dream Team and Mario and Luigi: Bowser's Inside Story.
An evil cackle is heard, followed by the screen rising to a shadowy figure. Lightning strikes, and a glimpse of the villain is shown. The villain then pours a syrup on an orb, and previous villains such as Cackletta, Fawful, Dark Star, Dark Bowser and Midbus return.