Items are a common aspect in games of all types, especially in those of the role-playing genre. MainFrame is no such exception, providing a plethora of items for players to use while traveling through Naahvelicon. Items are split into six categories: Weapons, Armor, Restorative, Power, Other, and Key.
There are ten categories of weapon within MainFrame, each dedicated to a specific character. Each weapon type has basic normal attacks, as well as a single (two in the case of Gunblades) type(s) of attack. Swords, Twin Blades, and Scythes are slashing weapons. Bludgeons, Rods, and Knuckles are bashing weapons. Twin Guns, Bows, and Cards are stabbing weapons. Gunblades vary between stabbing and slashing depending on the attack.
|Wooden Sword||None||Zelix's starting weapon|
|Stone Club||None||Beth's starting weapon|
|Holy Staff||None||Lisa's starting weapon|
|Metal Wrench||None||Alex's starting weapon|
|Shadow Blasters||Dark||Kirsty's starting weapon|
|Prism Blades||Light||Chris's starting weapon|
|Stone Fists||Earth||Brian's starting weapon|
|Forsaken Bow||Metal||Serina's starting weapon|
|Native Deck||Wind||Azure's starting weapon|
|Bit Slasher||Techno||Yuri's starting weapon|