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A Doctor Mushroom turns Mario into Doctor Mario who can throw pills so enemies rest for a while. This gives Mario the time he needs to jump on their heads. He can also give them viruses. The red virus makes the foes attack each other, the blue virus makes them walk in the other direction, and the yellow virus makes them smaller, and every five yellow-virused enemies you stomp on, you get a 1-Up Mushroom. It has not been seen in any games so far.
- It was once said that in the game Doctor Mario, Mario was stuck in his doctor form and you had to defeat the viruses or Mario would lose all his lives.